Temozolomide and tranilast synergistic antiproliferative effect on human glioblastoma multiforme cell line (U87MG)
نویسندگان
چکیده
منابع مشابه
In Vitro Radiosensitizing Effects of Temozolomide on U87MG Cell Lines of Human Glioblastoma Multiforme
Background: Glioma is the most common primary brain tumor with poor prognosis. Temozolomide (TMZ) has been used with irradiation (IR) to treat gliomas. The aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of TMZ when combined with high-dose and high-dose rate of gamma irradiation in vitro.Methods: Two ‘U87MG’ cell lines and skin fibroblast were cultured and ass...
متن کاملin vitro radiosensitizing effects of temozolomide on u87mg cell lines of human glioblastoma multiforme
background: glioma is the most common primary brain tumor with poor prognosis. temozolomide (tmz) has been used with irradiation (ir) to treat gliomas. the aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of tmz when combined with high-dose and high-dose rate of gamma irradiation in vitro. methods: two ‘u87mg’ cell lines and skin fibroblast were cultured and as...
متن کاملIn Vitro Radiosensitizing Effects of Temozolomide on U87MG Cell Lines of Human Glioblastoma Multiforme
BACKGROUND Glioma is the most common primary brain tumor with poor prognosis. Temozolomide (TMZ) has been used with irradiation (IR) to treat gliomas. The aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of TMZ when combined with high-dose and high-dose rate of gamma irradiation in vitro. METHODS Two 'U87MG' cell lines and skin fibroblast were cultured and as...
متن کاملPropolis changes the anticancer activity of temozolomide in U87MG human glioblastoma cell line
BACKGROUND Propolis is a honey bee product which contains many active compounds, such as CAPE or chrysin, and has many beneficial activities. Recently, its anti-tumor properties have been discussed. We have tested whether the ethanolic extract of propolis (EEP) interferes with temozolomide (TMZ) to inhibit U87MG cell line growth. METHODS The U87MG glioblastoma cell line was exposed to TMZ (10...
متن کاملthe synergistic effects of the combination of ciprofloxacin and temozolomide on human glioblastoma a-172 cell line
background: combination therapy has generated remarkable motivation in the clinical setting since it boosts the therapeutic potential of anticancer drugs. glioblastoma multiforme (gbm) is the most common and aggressive malignant brain tumor which affects patients in all ages, and being principally resistant to treatment. methods: in this study, temozolomide as a standard chemotherapeutic drug f...
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ژورنال
عنوان ژورنال: Medical Journal of The Islamic Republic of Iran
سال: 2019
ISSN: 1016-1430,2251-6840
DOI: 10.47176/mjiri.33.39